In 1995 NASA published it’s findings on the effects of common recreational drugs and toxins on the behavior and web building characteristics of spiders. It was only a preliminary report though and didn’t provide any insight into the long-term effects of various drugs upon the spiders’ behavior and web weaving.
Fortunately others have continued where NASA left off:
Spiders On Drugs – A Tangled Web Indeed
H/T to SwittersB & Fly Fishing for finding this great piece on YouTube.